Judith V M G Bovée Selected Research

Chondrosarcoma

5/2021	A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors.
11/2020	Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma.
1/2020	Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma.
12/2019	Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status.
12/2019	A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival.
4/2019	Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway.
1/2019	Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes.
1/2019	Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma.
9/2018	Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma.
1/2018	Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation.

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Judith V M G Bovée Research Topics

Disease

58	Neoplasms (Cancer) 10/2022 - 03/2004
40	Chondrosarcoma 05/2021 - 03/2004
25	Sarcoma (Soft Tissue Sarcoma) 01/2022 - 05/2013
17	Osteosarcoma (Osteogenic Sarcoma) 01/2022 - 07/2015
9	Neoplasm Metastasis (Metastasis) 11/2017 - 05/2009
7	Myxoid Liposarcoma 01/2021 - 09/2010
7	Leiomyosarcoma 01/2019 - 08/2013
6	Glioma (Gliomas) 05/2021 - 01/2013
6	Chondroma (Enchondroma) 11/2020 - 03/2004
4	Carcinogenesis 09/2021 - 08/2013
4	Hypoxia (Hypoxemia) 04/2019 - 04/2010
4	Enchondromatosis (Ollier Disease) 06/2015 - 12/2004
3	Cholangiocarcinoma 05/2021 - 10/2017
3	Synovial Sarcoma (Synovioma) 02/2021 - 04/2015
3	Pheochromocytoma 01/2021 - 11/2015
3	Paraganglioma (Paragangliomas) 01/2021 - 11/2015
3	Mesenchymal Chondrosarcoma 01/2019 - 03/2008
3	Ewing Sarcoma (Sarcoma, Ewing) 10/2016 - 02/2010
3	Fibroma (Fibromatosis) 12/2015 - 06/2005
2	Osteoblastoma 01/2022 - 01/2017
2	Bone Cysts (Bone Cyst) 12/2021 - 02/2010
2	Wounds and Injuries (Trauma) 01/2021 - 01/2019
2	Chondroblastoma 01/2020 - 09/2016
2	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 08/2009
2	Rhabdomyosarcoma 01/2020 - 01/2016
2	Leukemia 12/2019 - 01/2013
2	Margins of Excision 01/2019 - 01/2017
2	Genomic Instability 01/2017 - 09/2016
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 09/2016 - 02/2010
2	Liposarcoma 09/2016 - 01/2016
2	Leiomyoma (Uterine Fibroids) 01/2016 - 08/2013
2	Aggressive Fibromatosis (Desmoid) 12/2015 - 10/2013
2	Smooth Muscle Tumor 11/2015 - 08/2013

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2004
12	Biomarkers (Surrogate Marker)IBA 10/2022 - 04/2013
9	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 03/2007
9	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 05/2021 - 01/2013
8	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019 - 04/2013
7	Phosphotransferases (Kinase)IBA 12/2019 - 08/2009
6	RNA (Ribonucleic Acid)IBA 12/2021 - 01/2017
6	Pharmaceutical PreparationsIBA 01/2021 - 01/2015
6	Small Interfering RNA (siRNA)IBA 11/2020 - 09/2009
6	CateninsIBA 01/2018 - 08/2013
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 02/2010
5	alpha-hydroxyglutarateIBA 05/2021 - 01/2013
4	Keratins (Keratin)IBA 01/2020 - 06/2010
4	Histones (Histone)IBA 01/2020 - 01/2013
4	ABT-737IBA 09/2018 - 04/2013
4	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2018 - 11/2015
4	isocitric acid (isocitrate)IBA 12/2017 - 01/2013
4	ParaffinIBA 01/2017 - 05/2012
3	NAD (NADH)IBA 06/2021 - 12/2017
3	Chloroquine (Aralen)FDA LinkGeneric 05/2021 - 10/2017
3	Metformin (Glucophage)FDA LinkGeneric 05/2021 - 10/2017
3	Tyrosine Kinase InhibitorsIBA 01/2021 - 09/2010
3	Fumarate Hydratase (Fumarase)IBA 01/2018 - 11/2015
3	Formaldehyde (Formol)FDA Link 01/2017 - 12/2015
3	ChromatinIBA 01/2017 - 01/2009
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016 - 10/2012
3	Messenger RNA (mRNA)IBA 11/2015 - 03/2009
3	Plasminogen Activator Inhibitor 1IBA 09/2013 - 11/2009
3	Cyclin D1IBA 09/2013 - 09/2009
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 12/2021 - 01/2018
2	pazopanib FDA Link 11/2021 - 01/2018
2	AntigensIBA 08/2021 - 04/2015
2	Antimalarials (Antimalarial Agents)IBA 05/2021 - 10/2017
2	Hypoglycemic Agents (Hypoglycemics)IBA 05/2021 - 10/2017
2	Tricarboxylic AcidsIBA 01/2021 - 11/2015
2	Ifosfamide FDA LinkGeneric 01/2021 - 01/2020
2	sapanisertibIBA 01/2020 - 04/2019
2	Polysaccharides (Glycans)IBA 01/2020 - 01/2016
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2019 - 01/2016
2	SurvivinIBA 01/2019 - 08/2017
2	Histone Deacetylase InhibitorsIBA 01/2019 - 10/2016
2	Caspase 3 (Caspase-3)IBA 09/2018 - 09/2010
2	Cisplatin (Platino)FDA LinkGeneric 09/2018 - 04/2013
2	EnzymesIBA 01/2018 - 11/2015
2	matrigelIBA 01/2018 - 01/2016
2	CollagenIBA 12/2017 - 06/2012
2	Imatinib Mesylate (Gleevec)FDA Link 11/2017 - 08/2009
2	5-hydroxymethylcytosineIBA 01/2017 - 11/2015
2	histone H3 trimethyl Lys4IBA 01/2017 - 11/2015
2	Biological ProductsIBA 01/2016 - 03/2005
2	Insulin-Like PeptidesIBA 01/2016 - 07/2010
2	Galectin 1 (LGALS1)IBA 01/2016 - 04/2010
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2015 - 07/2013
2	Codon (Codons)IBA 07/2014 - 10/2013
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 05/2014 - 07/2013
2	Peptides (Polypeptides)IBA 04/2013 - 08/2009
2	Transforming Growth Factor beta (TGF-beta)IBA 10/2012 - 11/2009
2	Dasatinib (BMS 354825)FDA Link 09/2010 - 08/2009
2	Matrix Metalloproteinases (MMPs)IBA 07/2010 - 04/2010

Therapy/Procedure

23	Therapeutics 09/2021 - 03/2008
20	Drug Therapy (Chemotherapy) 01/2021 - 08/2005
17	Radiotherapy 01/2022 - 08/2005
5	Immunotherapy 08/2021 - 04/2015
2	Subcutaneous Injections 01/2022 - 03/2021
2	Drug Tapering 01/2021 - 01/2018
2	Lasers (Laser) 01/2020 - 07/2017
2	Aftercare (After-Treatment) 12/2019 - 09/2010